Phenanthrenes and derivatives
Medchemexpress LLC BCR-ABL1-IN-1 | 1488090-21-6 | 99.8% | C18H12F3N3O2 | 50 MG
BCR-ABL1-IN-1 is an inhibitor for ABL1 (64-515) with an IC50 of 8.7 nM. It can be used in research on diseases related to the central nervous system (CNS). It inhibits the proliferation of Ba/F3-BCR-ABL1-WT cells with an IC50 of 30 nM. This product is for research use only and not sold to patients.
- Inhibits ABL1 (64-515) with an IC50 of 8.7 nM.
- Can be used in research on diseases related to the central nervous system (CNS).
- Inhibits the proliferation of Ba/F3-BCR-ABL1-WT cells with an IC50 of 30 nM.
- Molecular weight is 359.30.
- Appears as a solid, white to off-white in color.
Medchemexpress LLC Aristolochic acid D (Aristolochic acid-IVa) | 17413-38-6 | 357.27 | 1 ML
Aristolochic acid D (Aristolochic acid-IVa) is an orally active inhibitor of PDE2 (IC50: 4.673 μM) and CDK2 (IC50: 25 μM) that is isolated from Aristolochia indica L. It demonstrates anti-inflammatory activity and is considered non-carcinogenic and non-nephrotoxic. This compound is suitable for research related to inflammation and tumor-related diseases.
- Orally active PDE2 inhibitor (IC50: 4.673 μM).
- CDK2 inhibitor (IC50: 25 μM).
- Isolated from Aristolochia indica L.
- Exhibits anti-inflammatory activity.
- Non-carcinogenic.
- Non-nephrotoxic.
- Useful in research for inflammation and tumor-related diseases.
Medchemexpress LLC Aristolochic acid C | 4849-90-5 | 327.25 | 5 MG
Aristolochic acid C is a derivative of Aristolochic acid. Aristolochic acid acts as a phospholipase A2 (PLA2) inhibitor, which interferes with cortical microtubule arrays and root growth in Arabidopsis.
- Derivative of Aristolochic acid
- Acts as a phospholipase A2 (PLA2) inhibitor
- Disrupts cortical microtubule arrays
- Interferes with root growth in Arabidopsis
Medchemexpress LLC 2H-1-Benzopyran-7-ol, 3,4-dihydro-3-(4-hydroxyphenyl)-4-(4-methoxyphenyl)-, (3R,4S)-rel- | 1213777-80-0 | 723112 | 99.6% | C22H20O4 | 25 MG
Triphen diol is a phenol diol derivative known for its excellent anticancer activity against pancreatic cancer and cholangiocarcinoma. It induces pancreatic cell apoptosis through both caspase-mediated and caspase-independent mechanisms, and is intended for research use only.
- Inhibits proliferation of pancreatic cells (IC50 values: 8 μM for HPAC and PANC-1; 0.8 μM for MIAPaCa-2).
- Induces caspase-dependent apoptosis in MIAPaCa-2 and PANC-1 cells (60% early-stage, 30% late-stage).
- Reduces Bcl-2 levels in MIAPaCa-2 and HPAC cell lines.
- Significantly inhibits tumor proliferation in male Balb/c nude mice with MIAPaCa2 cells.
- Shows enhanced efficacy when combined with gemcitabine in vivo.
Medchemexpress LLC Fullerene-C60 | 99685-96-8 | MFCD00151408 | 99.7% | 720.64 g/mol | C60 | 50 MG
Fullerene-C60 is a buckminsterfullerene (C60) molecular carbon compound supplied as a brown to black solid for biochemical and analytical research. It has molecular weight 720.64 g/mol and CAS 99685-96-8, and is provided at high purity for experimental use.
- High purity: 99.73%.
- Molecular formula: C60; molecular weight 720.64 g/mol.
- Physical form: brown to black solid powder.
- Low solubility: H2O < 0.1 mg/mL; DMSO < 1 mg/mL.
- Recommended storage: powder at -20°C (3 years) or 4°C (2 years).
- Suitable for biochemical assays and analytical studies.
AdipoGen Hypericin
Chemical. CAS 548-04-9. Formula C30H16O8. MW 504.5. Isolated from Hypericum perforatum. One of the principal active constituents of St. Johns Wort Hypericum perforatum. Hypericin is a photosensitive pigment/chromophore with bright red fluorescence emission lambdamax 594nm. Has a high triplet quantum yield and ability to produce considerable amounts of singlet oxygen and other ROS species when photoactivated. Antiviral, anticancer and antidepressant agent. Inactivates enveloped viruses including HIV. This photosensitizing agent has shown to induce apoptosis and necrosis in cancer cells during photodynamic therapy. Selective inhibitor of protein kinase C PKC. Has been shown to inhibit other kinases and targets such as EGFR-PTK, PI3K, CKII, MAPK and insulin receptor IR. Necrosis-avid contrast agent investigated for use in non-invasively targeting necrotic tissues, based on to be defined components in the phospholipid bilayer.
Medchemexpress LLC Aristolochic acid Va | 108779-46-0 | 357.27 | 1 MG
Aristolochic acid Va is a natural compound isolated from *Aristolochia* plants. This high-purity compound is intended for research use only, supporting a wide range of studies in natural product chemistry and biological activity.
- Natural compound isolated from Aristolochia plants.
- Suitable for various research applications.
- High purity for reliable experimental results.
- Available in multiple sizes for research flexibility.
Medchemexpress LLC Aristolochic acid D | 17413-38-6 | 357.27 | 5 MG
Aristolochic acid D | 17413-38-6 | 357.27 | 5 MG
Medchemexpress LLC Docosahexaenoic acid | 6217-54-5 | 98.8% | 200 MG
Docosahexaenoic acid (DHA) is an omega-3 fatty acid abundantly present in the brain and retina, crucial for development and maintaining normal function. Obtained from fish oil and maternal milk, DHA plays a vital role in cognitive abilities and neurological health.
- Essential for infant brain growth and functional development
- Maintains normal adult brain function
- Improves learning ability and memory
- Required for neural cell proliferation, migration, differentiation, and synaptogenesis
- Unique structure supports effective cell signaling
- Potent RXR ligand, activating RXRα at low micromolar concentrations
- Reduces reference memory errors
- Increases DHA content and DHA/arachidonic acid ratio in brain regions
- Exhibits neuroprotective actions in Parkinson's disease models
Cayman Chemical ArIstolochIc AcId 50mg
A PLA2 inhibitor (IC50 = 40 µM in human neutrophils); inhibits human synovial fluid PLA2-induced edema in a dose-dependent manner in vivo; inhibits hemolytic activity of the PLA2 enzymes TFV PL-X, TFV PL-Ia, and TFV PL-Ib from T. flavoviridis venom (IC50s = 4.6, 4.0, and 3.9 µM, respectively); enhances the edema-inducing activity of TFV PL-Ia and TFV PL-Ib; associated with progressive interstitial fibrosing nephropathy and upper urinary tract urothelial carcinomas
Medchemexpress LLC 6-Aminochrysene | 2642-98-0 | MFCD00003699 | 99.7% | 243.30 g/mol | C18H13N | 100 MG
6-Aminochrysene is an aromatic amine used in biochemical and toxicological research. The compound is supplied as a high-purity solid or as DMSO solutions for laboratory assays and analytical studies.
- High purity of 99.7% for accurate analytical results.
- Molecular formula C18H13N and molecular weight 243.30 g/mol.
- Available in small research quantities, including 100 mg and solution formats.
- Applicable to enzymatic metabolism, mutagenicity, and toxicology studies.
- Provided with purity and identity information appropriate for research use.
eMolecules Key Organics/BIONET Malonic acid 5mg 564178358 STR00614 95 000 141-82-2 104 061 C3H4O4
Key Organics/BIONET Malonic acid 5mg 564178358 STR00614 95 000 141-82-2 104 061 C3H4O4