Phenanthrenes and derivatives
Medchemexpress LLC Aristolochic acid Va | 108779-46-0 | 357.27 | 1 MG
Aristolochic acid Va is a natural compound isolated from *Aristolochia* plants. This high-purity compound is intended for research use only, supporting a wide range of studies in natural product chemistry and biological activity.
- Natural compound isolated from Aristolochia plants.
- Suitable for various research applications.
- High purity for reliable experimental results.
- Available in multiple sizes for research flexibility.
Medchemexpress LLC SKF 38393 hydrochloride | 62717-42-4 | MFCD00069248 | >98.0% | 291.77 g/mol | C16H18ClNO2 | 200MG
SKF 38393 hydrochloride is the hydrochloride salt of SKF-38393, a selective dopamine D1 receptor agonist with a reported IC50 of approximately 110 nM. Supplied as a research-grade solid analytical standard, it is used for in vitro pharmacology, receptor binding, and analytical assays. Not for human or clinical use.
- Selective D1 receptor agonist, reported IC50 ≈ 110 nM.
- Hydrochloride salt form improves solubility for biological assays.
- Molecular weight 291.77 g/mol.
- Chemical formula C16H18ClNO2.
- Provided as a solid analytical standard suitable for in vitro studies.
- Typical purities reported ≥98% by HPLC from third-party suppliers.
- Not for human or clinical use; for research only.
Medchemexpress LLC Lurasidone Hydrochloride | 367514-88-3 | 99.9% | C28H37ClN4O2S | 200 MG
Lurasidone Hydrochloride is a 5-HT Receptor Modulator that functions as an antagonist of both dopamine D2 and 5-HT7 receptors. It also acts as a partial agonist of the 5-HT1A receptor. This product is intended for research use only.
- Antagonist of dopamine D2 receptors with an IC50 of 1.68 nM
- Antagonist of 5-HT7 receptors with an IC50 of 0.495 nM
- Partial agonist of 5-HT1A receptors with an IC50 of 6.75 nM
- Demonstrates higher affinity for dopamine D2 and 5-HT2A receptors
Medchemexpress LLC Hypericin (standard) | 548-04-9 | 504.44 | 25 MG
Hypericin (Standard) is the analytical standard of Hypericin, a naturally occurring substance found in Hyperlcurn perforatum L. This product is intended for research and analytical applications, and is commonly used in qualitative, quantitative, and methodological research experiments in HPLC, GC, and MS.
- Inhibitor of PKC, MAO, dopamine-beta-hydroxylase, reverse transcriptase, telomerase and CYP
- Shows antitumor, antiviral, and antidepressive activities
- Can induce apoptosis
Medchemexpress LLC Aristolochic acid B | 475-80-9 | 311.25 | 5 MG
Aristolochic acid B (Aristolochic Acid II) is an orally active major component of aristolochic acid (AA). It can be isolated from plants of the genus Aristolochica. Aristolochic acid B forms DNA adducts, is mutagenic, and exhibits a greater carcinogenic risk in vivo than Aristolochic acid I.
- Target: DNA alkylator/crosslinker
- Research area: Cancer
- Mechanism: Forms DNA adducts and is mutagenic
- Carcinogenic risk: Exhibits greater carcinogenic risk in vivo than Aristolochic acid I
- Appearance: Solid
- Melting/freezing point: 270-272°C
Medchemexpress LLC Hypericin | 548-04-9 | 504.443 | 1 MG
Hypericin is a naturally occurring substance found in Hypericum perforatum L. It functions as an inhibitor of PKC (protein kinase C), MAO (monoaminoxidase), dopamine-beta-hydroxylase, reverse transcriptase, telomerase, and CYP (cytochrome P450). It exhibits antitumor, antiviral, and antidepressive activities, and can induce apoptosis.
- Inhibits PKC (protein kinase C)
- Inhibits MAO (monoaminoxidase)
- Inhibits dopamine-beta-hydroxylase
- Inhibits reverse transcriptase
- Inhibits telomerase
- Inhibits CYP (cytochrome P450)
- Shows antitumor activity
- Shows antiviral activity
- Shows antidepressive activity
- Induces apoptosis
- Relevant for infection research
- Relevant for neurological disease research
- Relevant for cancer research
Medchemexpress LLC Fullerene-C60 | 99685-96-8 | MFCD00151408 | 99.7% | 720.64 g/mol | C60 | 50 MG
Fullerene-C60 is a buckminsterfullerene (C60) molecular carbon compound supplied as a brown to black solid for biochemical and analytical research. It has molecular weight 720.64 g/mol and CAS 99685-96-8, and is provided at high purity for experimental use.
- High purity: 99.73%.
- Molecular formula: C60; molecular weight 720.64 g/mol.
- Physical form: brown to black solid powder.
- Low solubility: H2O < 0.1 mg/mL; DMSO < 1 mg/mL.
- Recommended storage: powder at -20°C (3 years) or 4°C (2 years).
- Suitable for biochemical assays and analytical studies.
Medchemexpress LLC Alprenolol (hydrochloride) | 13707-88-5 | 99.8% | 285.81 | 200 MG
Alprenolol hydrochloride is an orally active non-selective β-adrenoceptor antagonist and an antagonist of 5-HT1A and 5-HT1B receptors. It is used as an anti-hypertensive, anti-anginal, and anti-arrhythmic agent.
- Orally active non-selective β-adrenoceptor antagonist
- Antagonist of 5-HT1A and 5-HT1B receptors
- Used as an anti-hypertensive agent
- Used as an anti-anginal agent
- Used as an anti-arrhythmic agent
Medchemexpress LLC Vardenafil hydrochloride trihydrate | 330808-88-3 | 99.7% | 200 MG
Vardenafil hydrochloride trihydrate is a selective and orally active inhibitor of phosphodiesterase-5 (PDE5) with an IC50 of 0.7 nM. It shows inhibitory effects towards PDE1 and PDE6 with IC50s of 180 nM and 11 nM, respectively, while IC50s are >1000 nM for PDE3 and PDE4. It competitively inhibits cyclic guanosine monophosphate (cGMP) hydrolysis, which increases cGMP levels. It can be used for research related to erectile dysfunction, hepatitis, and diabetes.
- It is a selective and orally active inhibitor of phosphodiesterase-5 (PDE5).
- It has an IC50 of 0.7 nM for PDE5.
- It inhibits PDE1 and PDE6 with IC50s of 180 nM and 11 nM.
- It competitively inhibits cyclic guanosine monophosphate (cGMP) hydrolysis.
- It increases cGMP levels.
- It can be used for the research of erectile dysfunction.
- It can be used for the research of hepatitis.
- It can be used for the research of diabetes.
Medchemexpress LLC Hypericin | 548-04-9 | 98.0% | 504.44 g/mol | C30H16O8 | 10 MG
Hypericin is a photosensitive natural compound (C30H16O8) used in biochemical research as an inhibitor of protein kinase C (PKC) and monoamine oxidase (MAO). It is applied in studies of apoptosis, phototoxicity, antiviral activity, and antidepressant mechanisms, and is supplied as a solid or solution for in vitro experiments.
- Used as a PKC and MAO inhibitor in biochemical research.
- CAS number 548-04-9; molecular weight 504.44 g/mol.
- Purity typically 98.0% and appears as a brown to black solid.
- Soluble in DMSO (≈250 mg/mL with warming and ultrasonication).
- Storage: powder at -20°C (up to 3 years) or 4°C (up to 2 years); solutions -80°C (up to 6 months).
- Available in small research quantities such as 10 MG and solution formats.
Cayman Chemical 4-Methylpentanoic Acid-d12, Purity: ≥99% deuterated forms (d1-d12), CAS: 116287-57-1, 50 mg
An internal standard for the quantification of 4-methylpentanoic acid by GC- or LC-MS
TARGETMOL CHEMICALS INC MALONIC ACID 500MG
Also available in 25 mg 50 mg 100 mg 1000 mg 1 mL 10 mM (in DMSO) and bulk. Please contact Fisher for quotes. Malonic acid (propanedioic acid) is the archetypal example of a competitive inhibitor it acts against succinate dehydrogenase (complex II) in the respiratory electron transport chain. Malonic acid is found to be associated with malonyl-CoA decarboxylase deficiency which is an inborn error of metabolism. purity: 98%
Medchemexpress LLC Ilginatinib hydrochloride (NS-018 hydrochloride) | 1239358-85-0 | 98.9% | 425.89 | 200 MG
Ilginatinib hydrochloride (NS-018 hydrochloride) | 1239358-85-0 | 98.9% | 425.89 | 200 MG
Medchemexpress LLC Vardenafil hydrochloride | 224785-91-5 | 99.8% | 200 MG
Vardenafil hydrochloride is a selective and orally active inhibitor of phosphodiesterase-5 (PDE5) with an IC50 of 0.7 nM, showing lower inhibition of PDE1, PDE6, PDE3, and PDE4. It competitively inhibits cGMP hydrolysis, leading to increased cGMP levels. It is used for research of erectile dysfunction, hepatitis, and diabetes.
- Specifically inhibits cGMP hydrolysis by PDE5, increasing intracellular cGMP levels for increased dilation and blood flow.
- Exhibits facilitator effects in rats with cavernous nerve injury.
- Protects the liver against Con A-induced hepatitis in mice and decreases NF-κB expression.
- Prevents reduction of tissue cGMP levels and increased 3-NT generation in ZDF hearts.
Medchemexpress LLC Methacycline hydrochloride | 3963-95-9 | 99.3% | 200 MG
Methacycline hydrochloride is a tetracycline antibiotic that inhibits bacterial protein synthesis. It is also a potent epithelial-mesenchymal transition (EMT) inhibitor, blocking EMT in vitro and fibrogenesis in vivo without directly affecting TGF-β1 Smad signaling. This compound is an antimicrobial and has potential for pulmonary fibrosis.
- Inhibits bacterial protein synthesis
- Acts as a potent epithelial-mesenchymal transition (EMT) inhibitor
- Blocks EMT in vitro and fibrogenesis in vivo
- Demonstrates antimicrobial properties
- Shows potential for pulmonary fibrosis treatment
- Inhibits A549 EMT with an IC50 of approximately 5 μM
- Attenuates Bleomycin-induced canonical EMT markers
- Improves survival at Day 17 in vivo studies