Phenanthrenes and derivatives
Medchemexpress LLC Aristolochic acid D (Aristolochic acid-IVa) | 17413-38-6 | 357.27 | 1 MG
Aristolochic acid D (Aristolochic acid-IVa) is an orally active PDE2 and CDK2 inhibitor isolated from *Aristolochia indica L.* It exhibits anti-inflammatory activity and can be used in the research of inflammation and tumor-related diseases.
- Orally active PDE2 inhibitor
- Orally active CDK2 inhibitor
- Isolated from *Aristolochia indica L.*
- Exhibits anti-inflammatory activity
- Non-carcinogenic
- Non-nephrotoxic
- Can be used in inflammation research
- Can be used in tumor-related diseases research
Cayman Chemical ArIstolochIc AcId 25mg
A PLA2 inhibitor (IC50 = 40 µM in human neutrophils); inhibits human synovial fluid PLA2-induced edema in a dose-dependent manner in vivo; inhibits hemolytic activity of the PLA2 enzymes TFV PL-X, TFV PL-Ia, and TFV PL-Ib from T. flavoviridis venom (IC50s = 4.6, 4.0, and 3.9 µM, respectively); enhances the edema-inducing activity of TFV PL-Ia and TFV PL-Ib; associated with progressive interstitial fibrosing nephropathy and upper urinary tract urothelial carcinomas
Medchemexpress LLC Hypericin (standard) | 548-04-9 | 504.44 | 25 MG
Hypericin (Standard) is the analytical standard of Hypericin, a naturally occurring substance found in Hyperlcurn perforatum L. This product is intended for research and analytical applications, and is commonly used in qualitative, quantitative, and methodological research experiments in HPLC, GC, and MS.
- Inhibitor of PKC, MAO, dopamine-beta-hydroxylase, reverse transcriptase, telomerase and CYP
- Shows antitumor, antiviral, and antidepressive activities
- Can induce apoptosis
Medchemexpress LLC Hypericin | 548-04-9 | 98.0% | 504.44 g/mol | C30H16O8 | 10 MG
Hypericin is a photosensitive natural compound (C30H16O8) used in biochemical research as an inhibitor of protein kinase C (PKC) and monoamine oxidase (MAO). It is applied in studies of apoptosis, phototoxicity, antiviral activity, and antidepressant mechanisms, and is supplied as a solid or solution for in vitro experiments.
- Used as a PKC and MAO inhibitor in biochemical research.
- CAS number 548-04-9; molecular weight 504.44 g/mol.
- Purity typically 98.0% and appears as a brown to black solid.
- Soluble in DMSO (≈250 mg/mL with warming and ultrasonication).
- Storage: powder at -20°C (up to 3 years) or 4°C (up to 2 years); solutions -80°C (up to 6 months).
- Available in small research quantities such as 10 MG and solution formats.
Selleck Chemical LLC Hypericin S3273-5mg
Hypericin (Hyp HY) is a naturally occurring substance found in the common St John s Wort (Hypericum species) with antidepressive antineoplastic and antiviral (human immunodeficiency and hepatitis C virus) activities Hypericin has inhibitory effects on MAO (monoaminoxidase) PKC (protein kinase C) dopamine-beta-hydroxylase reverse transcriptase telomerase and CYP (cytochrome P450)
Medchemexpress LLC 2H-1-Benzopyran-7-ol, 3,4-dihydro-3-(4-hydroxyphenyl)-4-(4-methoxyphenyl)-, (3R,4S)-rel- | 1213777-80-0 | 723112 | 99.6% | C22H20O4 | 25 MG
Triphen diol is a phenol diol derivative known for its excellent anticancer activity against pancreatic cancer and cholangiocarcinoma. It induces pancreatic cell apoptosis through both caspase-mediated and caspase-independent mechanisms, and is intended for research use only.
- Inhibits proliferation of pancreatic cells (IC50 values: 8 μM for HPAC and PANC-1; 0.8 μM for MIAPaCa-2).
- Induces caspase-dependent apoptosis in MIAPaCa-2 and PANC-1 cells (60% early-stage, 30% late-stage).
- Reduces Bcl-2 levels in MIAPaCa-2 and HPAC cell lines.
- Significantly inhibits tumor proliferation in male Balb/c nude mice with MIAPaCa2 cells.
- Shows enhanced efficacy when combined with gemcitabine in vivo.
Medchemexpress LLC Lurasidone Hydrochloride | 367514-88-3 | 99.9% | C28H37ClN4O2S | 200 MG
Lurasidone Hydrochloride is a 5-HT Receptor Modulator that functions as an antagonist of both dopamine D2 and 5-HT7 receptors. It also acts as a partial agonist of the 5-HT1A receptor. This product is intended for research use only.
- Antagonist of dopamine D2 receptors with an IC50 of 1.68 nM
- Antagonist of 5-HT7 receptors with an IC50 of 0.495 nM
- Partial agonist of 5-HT1A receptors with an IC50 of 6.75 nM
- Demonstrates higher affinity for dopamine D2 and 5-HT2A receptors